COMPLEXATION STUDIES OF PHOSPHORUS CONTAINING POLYMACROCYCLIC COMPOUNDS

Macrocycles containing sulfur and phosphorus: Structure and complexation properties

Abst ra : The structure and complexation properties of macrocycles containing atoms from the second row of the periodic table (e.g., sulfur and phosphorus) have received less attention than the corresponding properties of macrocycles containing only first row atoms (e.g., oxygen and nitrogen). We describe results in two areas: macrocyclic thioethers for chelation of late transition metal ions, ...

Voltammetric Study of Cd2+ Complexation with some Compounds of Garlic

The complexation of Cd2+ by diallyl disulfide (DADS) and diallyl sulfide (DAS) has been studied by differential pulse voltammetry. Stability constants, (log β), of the 1:1 (PbL) and 1:2 (PbL2) complexes, where L = ligand, were found to be in the range of ca. 5.8 - 6.2 and 9.6 -10.6, respectively. Complex formation is accompanied with a significant decrease in the peak current and the shift of t...

Phosphorus compounds in animal tissues; the distribution of nucleic acids and other phosphorus-containing compounds in normal and malignant tissues.

Malignant tissues are distinguished from other types of tissues by their capacity for relatively unlimited and uncontrolled growth in the organism. The reason why neoplastic tissues grow continually, in contrast to embryonic tissues which grow only up to a certain point before they begin to differentiate, is a fundamental problem of cancer research. A study of the synthetic mechanisms of the ce...

Studies of bromine-oxidizable sulfur-containing compounds in mold metabolism.

Studies of enzyme inhibition by compounds containing small rings.

Our interest in the enzyme chemistry of compounds containing small rings developed from a speculative study of the inhibition of alcohol dehydrogenase by allylic alcohols (MacInnes et al., 1981) in which we found that 3-thioethylprop-2-en1-01 (I) was a potent inhibitor of this enzyme. Our original strategy was that oxidation of (I) would lead to an a,/?-unsaturated aldehyde to which a nucleophi...